Dataset Identification:
Resource Abstract:
- description: In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity
to impaired swim bladder inflation was investigated in experiments in which fathead minnows were exposed to the TPO inhibitor
2-mercaptobenzothiazole (MBT). Results show that anterior, but not posterior, swim bladder inflation was impacted by exposure
to MBT supporting the development of an AOP linking a specific thyroid-disrupting molecular initiating event to a significant
phenotypic outcome. Results also suggest an alternative short-term in vivo test with larval fathead minnows that could be
used to screen chemicals for thyroid disrupting activity and possibly distinguish thyroid disrupting modes of action. The
dataset contains information on TPO expression, thyroid hormone concentrations, and swim bladder inflation measurements in
larval fathead minnows. This dataset is associated with the following publication: Nelson, K., A. Schroeder , G. Ankley ,
B. Blackwell, C. Blanksma, S. Degitz , K. Jensen , R. Johnson , M. Kahl , D. Knapen, P. Kosian , R. Milsk, E. Randolph, T.
Saari, E. Stinckens, L. Vergauwen, and D. Villeneuve. Impaired anterior swim bladder inflation following exposure to the thyroid
peroxidase inhibitor 2-Mercaptobenzothiazole Part I: Fathead minnow. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY,
USA, 173: 192-203, (2016).; abstract: In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid
peroxidase (TPO) activity to impaired swim bladder inflation was investigated in experiments in which fathead minnows were
exposed to the TPO inhibitor 2-mercaptobenzothiazole (MBT). Results show that anterior, but not posterior, swim bladder inflation
was impacted by exposure to MBT supporting the development of an AOP linking a specific thyroid-disrupting molecular initiating
event to a significant phenotypic outcome. Results also suggest an alternative short-term in vivo test with larval fathead
minnows that could be used to screen chemicals for thyroid disrupting activity and possibly distinguish thyroid disrupting
modes of action. The dataset contains information on TPO expression, thyroid hormone concentrations, and swim bladder inflation
measurements in larval fathead minnows. This dataset is associated with the following publication: Nelson, K., A. Schroeder
, G. Ankley , B. Blackwell, C. Blanksma, S. Degitz , K. Jensen , R. Johnson , M. Kahl , D. Knapen, P. Kosian , R. Milsk, E.
Randolph, T. Saari, E. Stinckens, L. Vergauwen, and D. Villeneuve. Impaired anterior swim bladder inflation following exposure
to the thyroid peroxidase inhibitor 2-Mercaptobenzothiazole Part I: Fathead minnow. AQUATIC TOXICOLOGY. Elsevier Science Ltd,
New York, NY, USA, 173: 192-203, (2016).
Citation
- Title Larval fathead minnow swim bladder inflation following exposure to 2-mercaptobenzothiazole.
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- creation Date
2017-06-18T15:53:51.436774
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Metadata data stamp:
2018-08-06T21:49:34Z
Resource Maintenance Information
- maintenance or update frequency:
- notes: This metadata record was generated by an xslt transformation from a dc metadata record; Transform by Stephen M. Richard, based
on a transform by Damian Ulbricht. Run on 2018-08-06T21:49:34Z
Metadata contact
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pointOfContact
- organisation Name
CINERGI Metadata catalog
-
- Contact information
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- Address
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- electronic Mail Address cinergi@sdsc.edu
Metadata language
eng
Metadata character set encoding:
utf8
Metadata standard for this record:
ISO 19139 Geographic Information - Metadata - Implementation Specification
standard version:
2007
Metadata record identifier:
urn:dciso:metadataabout:b95d5336-baa7-4bd2-a250-5c597e71d439
Metadata record format is ISO19139 XML (MD_Metadata)